When it comes to vitamin B12 supplementation, the two most common forms are methylcobalamin and cyanocobalamin. At our IV Therapy & Wellness practice, we prioritize the use of methylcobalamin for several compelling reasons:


1. Bioavailability and Absorption

  • Methylcobalamin: This form is directly active in the human body, meaning it doesn’t require conversion. It is readily absorbed and utilized by cells, particularly in the nervous system and for DNA synthesis.
  • Cyanocobalamin: This synthetic form must be converted by the body into an active form (methylcobalamin or adenosylcobalamin). This additional step can reduce its effectiveness, especially in individuals with certain metabolic or enzymatic deficiencies. **We're talking to all of you with the MTHFR gene mutation**

2. Safety and Natural Presence

  • Methylcobalamin: Naturally occurring in food sources and in the human body, methylcobalamin is considered safer with no known toxic effects even at high doses. It is also preferred in clinical settings for its well-established safety profile.
  • Cyanocobalamin: Contains a cyanide molecule, which, while present in very small amounts, can be a concern for detoxification processes in the body. For individuals with compromised detoxification pathways, methylcobalamin is a safer option.

3. Neurological Benefits

  • Methylcobalamin: Particularly effective in supporting neurological health. It plays a crucial role in the maintenance of the myelin sheath, which protects nerve fibers and ensures proper transmission of nerve impulses. This makes it beneficial for patients with neurological conditions or symptoms.
  • Cyanocobalamin: While it can also support neurological health, its indirect nature means it may not be as effective for individuals with specific neurological needs or deficiencies.

4. Energy Production and Detoxification

  • Methylcobalamin: Supports energy production at the cellular level more efficiently by aiding in the conversion of homocysteine to methionine, a crucial process for DNA synthesis and repair. It also helps in the detoxification of harmful substances.
  • Cyanocobalamin: Though it contributes to energy production and detoxification, its efficiency is lower due to the necessary conversion process.

5. Patient Preference and Outcomes

  • Methylcobalamin: Feedback from our patients indicates a preference for methylcobalamin, with many reporting improved energy levels, mental clarity, and overall well-being. The direct benefits and rapid improvement in symptoms make it a popular choice.
  • Cyanocobalamin: Although effective, it tends to have a slower onset of noticeable benefits compared to methylcobalamin.


In summary, we prefer methylcobalamin in our IV Therapy & Wellness practice because it offers superior bioavailability, safety, neurological benefits, and overall effectiveness in improving patient outcomes. By choosing methylcobalamin, we ensure our clients receive the highest quality care tailored to their specific health needs, enhancing their journey to optimal wellness.

Krystle Maynard

Krystle Maynard

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